ea0070aep321 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020
Durmaz Himmet
, Evranos Ogmen Berna
, Ahmadova Konul
, Kucukcongar Yavas Aynur
, Keskin Caglar
, Dirikoc Ahmet
, Cakir Bekir
Background: Alstrom syndrome is a rare autosomal recessive genetic disorder characterised by vision loss, hearing loss, childhood obesity, insulin resistance and hyperinsulinemia, type 2 diabetes, hypertriglyceridemia, cardiomyopathy, and progressive pulmonary, hepatic, and renal dysfunction. Hyperinsulinemia develops early, and pancreatic islets show beta-cell proliferation, thus suggesting that both insulin resistance and increased insulin secretion might contribute to gluco...